Functional genomics and proteomics: charting a multidimensional map of the yeast cell

被引：97

作者：

Bader, GD

Heilbut, A

Andrews, B

Tyers, M

Hughes, T

Boone, C

机构：

[1] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON M5S 1A8, Canada

[2] Mem Sloan Kettering Canc Ctr, Computat Biol Ctr, New York, NY 10021 USA

[3] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[4] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 07期

关键词：

D O I：

10.1016/S0962-8924(03)00127-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The challenge of large-scale functional genomics projects is to build a comprehensive map of the cell including genome sequence and gene expression data, information on protein localization, structure, function and expression, post-translational modifications, molecular and genetic interactions and phenotypic descriptions. Some of this broad set of functional genomics data has been already assembled for the budding yeast. Even though molecular cartography of the yeast cell is still far from comprehensive, functional genomics has begun to forge connections between disparate cellular events and to foster numerous hypotheses. Here we review several different genomics and proteomics technologies and describe bioinformatics methods for exploring these data to make new discoveries.

引用

页码：344 / 356

页数：13

共 138 条

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