Exploring chemical space with organometallics: Ruthenium complexes as protein kinase inhibitors

被引：124

作者：

Meggers, Eric ^{[1
]}

Atilla-Gokcumen, G. Ekin ^{[1
]}

Bregman, Howard ^{[1
]}

Maksimoska, Jasna ^{[1
]}

Mulcahy, Seann P. ^{[1
]}

Pagano, Nicholas ^{[1
]}

Williams, Douglas S. ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

SYNLETT | 2007年 / 08期

关键词：

bioorganometallic chemistry; protein kinases; inhibitors; ruthenium; mammalian cells; GLYCOGEN-SYNTHASE KINASE-3-BETA; BIOORGANOMETALLIC CHEMISTRY; POTENT INHIBITORS; CELL BIOLOGY; ACTIVE-SITE; P53; STAUROSPORINE; LITHIUM; ZEBRAFISH; PATHWAY;

D O I：

10.1055/s-2007-973893

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Complementing organic elements with a metal center provides new opportunities for building three-dimensional structures with unique and defined shapes. Such access to unexplored chemical space may lead to the discovery of molecules with unprecedented properties. Along these tines, this account article describes our successful design of highly potent and selective ruthenium-based inhibitors for the protein kinases GSK-3 and Pim-1 by using the class of indolocarbazole alkaloids as a lead structure. The described ruthenium complexes are kinetically inert scaffolds in which the ruthenium has the function to organize the orientation of the organic ligands in the three-dimensional space.

引用

页码：1177 / 1189

页数：13

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