A eukaryotic gene family related to retroelement integrases

被引：26

作者：

Gao, X ^{[1
]}

Voytas, DF ^{[1
]}

机构：

[1] Iowa State Univ, Dept Genet Dev & Cell Biol, Ames, IA 50011 USA

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 03期

关键词：

D O I：

10.1016/j.tig.2005.01.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Proteins encoded by mobile genetic elements occasionally assume cellular roles. Telomerase, for example, is a reverse transcriptase that replicates chromosome ends, and Rag1 is a transposase that mediates immunoglobulin gene rearrangements. In this article, we report cellular genes related to integrases that are not associated with a retrovirus or retrotransposon. These integrases are found in diverse eukaryotes and are evolving under functional constraint. We propose that the cellular integrases have assumed a host role and, like their retroelement counterparts, probably function in DNA metabolism.

引用

页码：133 / 137

页数：5

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