Carbohydrate based vaccines

被引：93

作者：

Kuberan, B ^{[1
]}

Lindhardt, RJ ^{[1
]}

机构：

[1] Univ Iowa, Dept Chem & Biochem Engn, Dept Chem, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA

来源：

CURRENT ORGANIC CHEMISTRY | 2000年 / 4卷 / 06期

关键词：

D O I：

10.2174/1385272003376111

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Vaccination is the most cost-efficient and the most powerful medical intervention in the control, prevention and eradication of many diseases that affect human population. Capsular polysaccharide based vaccines have been in use for many decades providing immunity against various bacterial infections. The advent of new efficient and sensitive analytical and synthetic methods in carbohydrate chemistry, together with our increased understanding of glycobiology and glycoimmunology, makes the development of carbohydrate based vaccines against various cancers possible. This review article describes the biological basis of vaccination and summarizes the recent progress in the development of carbohydrate based glycoconjugate vaccines with particular emphasis on structure, function and chemistry of glycoconjugates.

引用

页码：653 / 677

页数：25

共 130 条

[91] Vaccines prepared with sialyl-Tn and sialyl-Tn trimers using the 4-(4-maleimidomethyl)cyclohexane-1-carboxyl hydrazide linker group result in optimal antibody titers against ovine submaxillary mucin and sialyl-Tn-positive tumor cells [J].