Rational design of a fluorescent hydrogen peroxide probe based on the umbelliferone fluorophore

被引：82

作者：

Du, Lupei

Li, Minyong

Zheng, Shilong

Wang, Binghe ^{[1
]}

机构：

[1] Georgia State Univ, Dept Chem, Atlanta, GA 30302 USA

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 19期

基金：

美国国家卫生研究院;

关键词：

hydrogen peroxide; reactive oxygen species (ROS); hydroxycoumarin; umbelliferone; fluorescence;

D O I：

10.1016/j.tetlet.2008.03.063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, we report a novel water-soluble umbelliferone-based fluorescent probe for hydrogen peroxide. This probe shows very large increases (up to 100-fold) in fluorescent intensity upon reaction with hydrogen peroxide, and good selectivity over other reactive oxygen species (ROS). (C) 2008 Elsevier Ltd. All rights reserved.

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页码：3045 / 3048

页数：4

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