Synthesis and antioxidant efficiency of a new amphiphilic spin-trap derived from PBN and lipoic acid

被引：17

作者：

Durand, G

Polidori, A

Salles, JP

Prost, M

Durand, P

Pucci, B

机构：

[1] Fac Sci, Lab Chim BioOrgan & Syst Mol Vectoriels, F-84000 Avignon, France

[2] Targeting Syst Pharma, F-13510 Eguilles, France

[3] Ctr Europeen Rech & Analyses, F-21560 Couternon, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(03)00545-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The synthesis of a new amphiphilic antioxidant called PBNLP and derived from both alpha-phenyl-N-tert-butyl nitrone (PBN) and lipoic acid was described. Grafting a lactobionamide moiety onto the aromatic group of the PBN provided the water solubility of this compound. In vitro preliminary biological evaluations of its antioxidant capacity were performed using the KRL biological test based on free radical-induced hemolysis. The PBNLP induces a protection of erythrocytes against exogenous free radicals higher than that measured with lipoic acid or PBN alone or with lipoic acid or PBN derivatives in admixtures. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：2673 / 2676

页数：4

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