Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala

被引：158

作者：

Murray, Elisabeth A. ^{[1
]}

Wise, Steven P. ^{[2
]}

Drevets, Wayne C. ^{[3
,4
]}

机构：

[1] NIMH, Sect Neurobiol Learning & Memory, Neuropsychol Lab, NIH, Bethesda, MD 20892 USA

[2] Olschefskie Inst Neurobiol Knowledge, Potomac, MD USA

[3] Laureate Inst Brain Res, Tulsa, OK USA

[4] Univ Oklahoma, Coll Med, Tulsa, OK USA

来源：

BIOLOGICAL PSYCHIATRY | 2011年 / 69卷 / 12期

关键词：

Animal models; devaluation; emotion; frontal lobe function; mood; primate research; reversal; reward; self-esteem; self-reflection; self-valuation; self-worth; DEEP BRAIN-STIMULATION; ORBITOFRONTAL CORTEX; ANTERIOR CINGULATE; BASOLATERAL AMYGDALA; DECISION-MAKING; NEURAL RESPONSE; ARCHITECTONIC SUBDIVISION; ANTIDEPRESSANT TREATMENT; TRYPTOPHAN DEPLETION; UNMEDICATED PATIENTS;

D O I：

10.1016/j.biopsych.2010.09.041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Despite considerable effort, the localization of dysfunction in major depressive disorder (MDD) remains poorly understood. We present a hypothesis about its localization that builds on recent findings from primate neuropsychology. The hypothesis has four key components: a deficit in the valuation of "self" underlies the core disorder in MDD; the medial frontal cortex represents "self"; interactions between the amygdala and cortical representations update their valuation; and inefficiency in using positive feedback by orbital prefrontal cortex contributes to MDD.

引用

页码：E43 / E54

页数：12

共 134 条

[41] Coherence and specificity of information-processing biases in depression and social phobia [J].

Gotlib, IH ;

Kasch, KL ;

Traill, S ;

Joormann, J ;

Arnow, BA ;

Johnson, SL .

JOURNAL OF ABNORMAL PSYCHOLOGY, 2004, 113 (03) :386-398

[42] The primate basal ganglia: parallel and integrative networks [J].

Haber, SN .

JOURNAL OF CHEMICAL NEUROANATOMY, 2003, 26 (04) :317-330

[43] The anterior cingulate and reward-guided selection of actions [J].

Hadland, KA ;

Rushworth, MFS ;

Gaffan, D ;

Passingham, RE .

JOURNAL OF NEUROPHYSIOLOGY, 2003, 89 (02) :1161-1164

[44] Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targeting Clinical article [J].

Hamani, Clement ;

Mayberg, Helen ;

Snyder, Brian ;

Giacobbe, Peter ;

Kennedy, Sidney ;

Lozano, Andres M. .

JOURNAL OF NEUROSURGERY, 2009, 111 (06) :1209-1215

[45] Discovering endophenotypes for major depression [J].

Hasler, G ;

Drevets, WC ;

Manji, HK ;

Charney, DS .

NEUROPSYCHOPHARMACOLOGY, 2004, 29 (10) :1765-1781

[46] Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects [J].

Hasler, Gregor ;

Fromm, Stephen ;

Carlson, Paul J. ;

Luckenbaugh, David A. ;

Waldeciz, Tracy ;

Geraci, Marilla ;

Roiser, Jonathan P. ;

Neumeister, Alexander ;

Meyers, Noah ;

Charney, Dennis S. ;

Drevets, Wayne C. .

ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (05) :521-531

[47] The construction system of the brain [J].

Hassabis, Demis ;

Maguire, Eleanor A. .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2009, 364 (1521) :1263-1271

[48]

Hatfield T, 1996, J NEUROSCI, V16, P5256

[49] Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation [J].

Heller, Aaron S. ;

Johnstone, Tom ;

Shackman, Alexander J. ;

Light, Sharee N. ;

Peterson, Michael J. ;

Kolden, Gregory G. ;

Kalin, Ned H. ;

Davidson, Richard J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (52) :22445-22450

[50]

Hirayasu Y, 1999, AM J PSYCHIAT, V156, P1091

← 1 2 3 4 5 6 7 8 9 10 →