Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala

被引：158

作者：

Murray, Elisabeth A. ^{[1
]}

Wise, Steven P. ^{[2
]}

Drevets, Wayne C. ^{[3
,4
]}

机构：

[1] NIMH, Sect Neurobiol Learning & Memory, Neuropsychol Lab, NIH, Bethesda, MD 20892 USA

[2] Olschefskie Inst Neurobiol Knowledge, Potomac, MD USA

[3] Laureate Inst Brain Res, Tulsa, OK USA

[4] Univ Oklahoma, Coll Med, Tulsa, OK USA

来源：

BIOLOGICAL PSYCHIATRY | 2011年 / 69卷 / 12期

关键词：

Animal models; devaluation; emotion; frontal lobe function; mood; primate research; reversal; reward; self-esteem; self-reflection; self-valuation; self-worth; DEEP BRAIN-STIMULATION; ORBITOFRONTAL CORTEX; ANTERIOR CINGULATE; BASOLATERAL AMYGDALA; DECISION-MAKING; NEURAL RESPONSE; ARCHITECTONIC SUBDIVISION; ANTIDEPRESSANT TREATMENT; TRYPTOPHAN DEPLETION; UNMEDICATED PATIENTS;

D O I：

10.1016/j.biopsych.2010.09.041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Despite considerable effort, the localization of dysfunction in major depressive disorder (MDD) remains poorly understood. We present a hypothesis about its localization that builds on recent findings from primate neuropsychology. The hypothesis has four key components: a deficit in the valuation of "self" underlies the core disorder in MDD; the medial frontal cortex represents "self"; interactions between the amygdala and cortical representations update their valuation; and inefficiency in using positive feedback by orbital prefrontal cortex contributes to MDD.

引用

页码：E43 / E54

页数：12

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