Transition-metal-free Sonogashira-type coupling reactions in water

被引：83

作者：

Appukkuttan, P ^{[1
]}

Dehaen, W ^{[1
]}

Van der Eycken, E ^{[1
]}

机构：

[1] Univ Louvain, Dept Chem, B-3001 Louvain, Belgium

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 24期

关键词：

cross-coupling; microwaves; transition metals; water chemistry;

D O I：

10.1002/ejoc.200300587

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microwave-assisted transition-metal-free Sonogashira-type coupling reactions are described. The reactions are run in water as the sole solvent, without the need for copper(I) or any transition-metal-phosphane complex. The scope of the methodology was tested by reaction of a wide variety of aryl halides and heteroaryl halides. The reaction was also investigated under conventional heating conditions. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

引用

页码：4713 / 4716

页数：4

共 34 条

[1] A copper- and amine-free Sonogashira-type coupling procedure catalyzed by oxime palladacycles [J].