Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles

被引：816

作者：

Yang, Kai ^{[1
]}

Hu, Lilei ^{[1
]}

Ma, Xingxing ^{[2
]}

Ye, Shuoqi ^{[3
]}

Cheng, Liang ^{[1
]}

Shi, Xiaoze ^{[1
]}

Li, Changhui ^{[3
]}

Li, Yonggang ^{[2
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Inst Funct Nano & Soft Mat Lab FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Radiol, Suzhou 215006, Jiangsu, Peoples R China

[3] Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 14期

基金：

中国国家自然科学基金;

关键词：

graphene oxide nanocomposites; magnetic resonance imaging; photoacoustic imaging; photothermal therapy; multimodal imaging; GOLD NANOCAGES; CARBON NANOTUBES; CANCER-THERAPY; DRUG-DELIVERY; OXIDE; PLATFORM; LONG; MICE; FABRICATION; OXIDATION;

D O I：

10.1002/adma.201104964

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, a nanoscale reduced graphene oxide-iron oxide nanoparticle (RGO-IONP) complex is noncovalently functionalized with polyethylene glycol (PEG), obtaining a RGO-IONP-PEG nanocomposite with excellent physiological stability, strong NIR optical absorbance, and superparamagnetic properties. Using this theranostic nanoprobe, in-vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for effective photothermal ablation of tumors in mice. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1868 / 1872

页数：5

共 48 条

[1]

[Anonymous], 2011, Angewandte Chemie

[2] Preparation of Novel 3D Graphene Networks for Supercapacitor Applications [J].

Cao, Xiehong ;

Shi, Yumeng ;

Shi, Wenhui ;

Lu, Gang ;

Huang, Xiao ;

Yan, Qingyu ;

Zhang, Qichun ;

Zhang, Hua .

SMALL, 2011, 7 (22) :3163-3168

[3] Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells [J].

Chen, Jingyi ;

Wang, Danling ;

Xi, Jiefeng ;

Au, Leslie ;

Siekkinen, Andy ;

Warsen, Addie ;

Li, Zhi-Yuan ;

Zhang, Hui ;

Xia, Younan ;

Li, Xingde .

NANO LETTERS, 2007, 7 (05) :1318-1322

[4] Composites of Aminodextran-Coated Fe3O4 Nanoparticles and Graphene Oxide for Cellular Magnetic Resonance Imaging [J].

Chen, Weihong ;

Yi, Peiwei ;

Zhang, Yi ;

Zhang, Liming ;

Deng, Zongwu ;

Zhang, Zhijun .

ACS APPLIED MATERIALS & INTERFACES, 2011, 3 (10) :4085-4091

[5] Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy [J].

Cheng, Liang ;

Yang, Kai ;

Li, Yonggang ;

Zeng, Xiao ;

Shao, Mingwang ;

Lee, Shuit-Tong ;

Liu, Zhuang .

BIOMATERIALS, 2012, 33 (07) :2215-2222

[6] Carbon nanotubes as photoacoustic molecular imaging agents in living mice [J].

De La Zerda, Adam ;

Zavaleta, Cristina ;

Keren, Shay ;

Vaithilingam, Srikant ;

Bodapati, Sunil ;

Liu, Zhuang ;

Levi, Jelena ;

Smith, Bryan R. ;

Ma, Te-Jen ;

Oralkan, Omer ;

Cheng, Zhen ;

Chen, Xiaoyuan ;

Dai, Hongjie ;

Khuri-Yakub, Butrus T. ;

Gambhir, Sanjiv S. .

NATURE NANOTECHNOLOGY, 2008, 3 (09) :557-562

[7] Minimizing Oxidation and Stable Nanoscale Dispersion Improves the Biocompatibility of Graphene in the Lung [J].

Duch, Matthew C. ;

Budinger, G. R. Scott ;

Liang, Yu Teng ;

Soberanes, Saul ;

Urich, Daniela ;

Chiarella, Sergio E. ;

Campochiaro, Laura A. ;

Gonzalez, Angel ;

Chandel, Navdeep S. ;

Hersam, Mark C. ;

Mutlu, Goekhan M. .

NANO LETTERS, 2011, 11 (12) :5201-5207

[8] Graphene based gene transfection [J].

Feng, Liangzhu ;

Zhang, Shuai ;

Liu, Zhuang .

NANOSCALE, 2011, 3 (03) :1252-1257

[9] Multifunctional Nanoemulsion Platform for Imaging Guided Therapy Evaluated in Experimental Cancer [J].

Gianella, Anita ;

Jarzyna, Peter A. ;

Mani, Venkatesh ;

Ramachandran, Sarayu ;

Calcagno, Claudia ;

Tang, Jun ;

Kann, Benjamin ;

Dijk, Wouter J. R. ;

Thijssen, Victor L. ;

Griffioen, Arjan W. ;

Storm, Gert ;

Fayad, Zahi A. ;

Mulder, Willem J. M. .

ACS NANO, 2011, 5 (06) :4422-4433

[10] Centimeter-Long and Large-Scale Micropatterns of Reduced Graphene Oxide Films: Fabrication and Sensing Applications [J].

He, Qiyuan ;

Sudibya, Herry Gunadi ;

Yin, Zongyou ;

Wu, Shixin ;

Li, Hai ;

Boey, Freddy ;

Huang, Wei ;

Chen, Peng ;

Zhang, Hua .

ACS NANO, 2010, 4 (06) :3201-3208

← 1 2 3 4 5 →