Synthesis of Trifluoroethyl-Substituted Ketones from Aldehydes and Cyclohexanones

被引：122

作者：

Morandi, Bill ^{[1
]}

Carreira, Erick M. ^{[1
]}

机构：

[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 39期

关键词：

cyclic ketones; homologation; synthetic methods; trifluoromethyl ketones; zirconium; ION CATALYZED HOMOLOGATION; SILYL ENOL ETHERS; ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION; MILD ELECTROPHILIC TRIFLUOROMETHYLATION; RADICAL TRIFLUOROMETHYLATION; ETHYL DIAZOACETATE; TITANIUM ATE; FLUORINE; ESTERS; 2,2,2-TRIFLUORODIAZOETHANE;

D O I：

10.1002/anie.201103526

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A trifluoromethylated symphony! A new transformation involving trifluoromethyl diazomethane generated in situ has been developed that allows direct access to trifluoroethyl ketone derivatives from aldehyde and cyclohexanone compounds (see scheme). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：9085 / 9088

页数：4

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