Proline-mediated enantioselective construction of tetrahydropyrans via a domino aidol/acetalization reaction

被引：34

作者：

Hazelard, Damien ^{[1
]}

Ishikawa, Hayato ^{[1
]}

Hashizume, Daisuke ^{[2
]}

Koshino, Hiroyuki ^{[2
]}

Hayashi, Yujiro ^{[1
]}

机构：

[1] Tokyo Univ Sci, Dept Ind Chem, Fac Engn, Shinjuku Ku, Tokyo 1628601, Japan

[2] RIKEN, Wako, Saitama 3510198, Japan

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 07期

关键词：

D O I：

10.1021/ol8002223

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly enantioselective synthesis of tetra hydropyrans was accomplished via a domino proline-mediated aldol reaction/intramolecular acetal formation from an aldehyde and inexpensive aqueous tetrahydro-2H-pyran-2,6-diol as a five-carbon unit.

引用

页码：1445 / 1448

页数：4

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