Chemotaxis in cancer

被引：713

作者：

Roussos, Evanthia T. ^{[1
]}

Condeelis, John S. ^{[1
]}

Patsialou, Antonia ^{[1
]}

机构：

[1] Yeshiva Univ, Dept Anat & Struct Biol, Program Tumor Microenvironm & Metastasis, Albert Einstein Coll Med, Bronx, NY 10461 USA

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 08期

基金：

美国国家卫生研究院;

关键词：

COLLECTIVE CELL-MIGRATION; ENDOTHELIAL GROWTH-FACTOR; METASTATIC BREAST-CANCER; CIRCULATING TUMOR-CELLS; ZEBRAFISH LATERAL-LINE; MOUSE MAMMARY-TUMORS; INVASION IN-VIVO; CARCINOMA-CELLS; DICTYOSTELIUM-DISCOIDEUM; EUKARYOTIC CHEMOTAXIS;

D O I：

10.1038/nrc3078

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.

引用

页码：573 / 587

页数：15

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