Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa

被引：192

作者：

Evans, K

Passador, L

Srikumar, R

Tsang, E

Nezezon, J

Poole, K ^{[1
]}

机构：

[1] Queens Univ, Dept Microbiol & Immunol, Kingston, ON K7L 3N6, Canada

[2] Univ Rochester, Med Ctr, Dept Microbiol & Immunol, Rochester, NY 14642 USA

来源：

JOURNAL OF BACTERIOLOGY | 1998年 / 180卷 / 20期

关键词：

D O I：

10.1128/JB.180.20.5443-5447.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Pseudomonas aeruginosa nalB mutants which hyperexpress the MexAB-OprM multidrug efflux system produce reduced levels of several extracellular virulence factors known to be regulated by quorum sensing. Such mutants also produce less acylated homoserine lactone autoinducer PAI-I, consistent with an observed reduction in lasI expression. These data suggest that PAI-1 is a substrate for MexAB-OprM, and its resulting exclusion from cells hyperexpressing MexAB-OprM limits PAI-l-dependent activation of lasI and the virulence genes.

引用

页码：5443 / 5447

页数：5

共 44 条

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