Oxidation of proteins: Basic principles and perspectives for blood proteomics

被引：54

作者：

Barelli, Stefano ^{[1
]}

Canellini, Giorgia ^{[1
]}

Thadikkaran, Lynne ^{[1
]}

Crettaz, David ^{[1
]}

Quadroni, Manfredo ^{[2
]}

Rossier, Joeel S. ^{[3
]}

Tissot, Jean-Daniel ^{[1
]}

Lion, Niels ^{[1
,4
]}

机构：

[1] Serv Reg Vaudois Transfus Sanguine, CH-1005 Lausanne, Switzerland

[2] Fac Biol & Med Lausanne, Inst Biochim, Epalinges, Switzerland

[3] DiagnoSwiss SA, Monthey, Switzerland

[4] Ecole Polytech Fed Lausanne, Lab Electrochim Phys & Analyt, CH-1015 Lausanne, Switzerland

来源：

PROTEOMICS CLINICAL APPLICATIONS | 2008年 / 2卷 / 02期

关键词：

blood; oxidative stress; oxidation; plasma; red blood cell;

D O I：

10.1002/prca.200780009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein oxidation mechanisms result in a wide array of modifications, from backbone cleavage or protein crosslinking to more subtle modifications such as side chain oxidations. Protein oxidation occurs as part of normal regulatory processes, as a defence mechanism against oxidative stress, or as a deleterious processes when antioxidant defences are overcome. Because blood is continually exposed to reactive oxygen and nitrogen species, blood proteomics should inherently adopt redox proteomic strategies. In this review, we recall the biochemical basis of protein oxidation, review the proteomic methodologies applied to analyse redox modifications, and highlight some physiological and in vitro responses to oxidative stress of various blood components.

引用

页码：142 / 157

页数：16

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