Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent

被引：25

作者：

Ema, T ^{[1
]}

Kageyama, M ^{[1
]}

Korenaga, T ^{[1
]}

Sakai, T ^{[1
]}

机构：

[1] Okayama Univ, Fac Engn, Dept Appl Chem, Okayama 7008530, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 24期

关键词：

D O I：

10.1016/j.tetasy.2003.09.040

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120degreesC. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40 120degreesC, with the highest conversion (39%) at 80-90degreesC. The mechanism of high enantioselectivity retained even at 120degreesC is also described briefly. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3943 / 3947

页数：5

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