A new indole alkaloid and anti-inflammatory constituents from Strychnos cathayensis

被引：15

作者：

Chen, Jih-Jung ^{[1
]}

Luo, Yn-Ting ^{[1
]}

Hwang, Tsong-Long ^{[2
]}

Sung, Ping-Jyun ^{[3
]}

Wang, Tai-Chi ^{[1
]}

Chen, Ih-Sheng ^{[4
]}

机构：

[1] Tajen Univ, Grad Inst Pharmaceut Technol, Pingtung 907, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[3] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[4] Kaohsiung Med Univ, Coll Pharm, Fac Pharm, Kaohsiung 807, Taiwan

来源：

CHEMISTRY & BIODIVERSITY | 2008年 / 5卷 / 07期

关键词：

D O I：

10.1002/cbdv.200890122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new indole alkaloid, 11,12-dimethoxyhenningsamine (1), was isolated from the roots of Strychnos cathayensis, together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 11-methoxy-henningsamine (3) and aesculetin dimethyl ether (4) exhibited potent inhibition (IC50 <5.5 mu g/ml) on superoxide-anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/ cytochalasin B.

引用

页码：1345 / 1352

页数：8

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