Novel epoxyfuranoid lignans and antitubercular constituents from the leaves of Beilschmiedia tsangii

被引：49

作者：

Chen, Jih-Jung ^{[1
]}

Chou, En-Tzu

Peng, Chien-Fang

Chen, Ih-Sheng

Yang, Sheng-Zehn

Huang, Hung-Yi

机构：

[1] Tajen Univ, Grad Inst Pharmaceut Technol, Pingtung 907, Taiwan

[2] Kaohsiung Med Univ, Coll Hlth Sci, Fac Biomed Lab Sci, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Grad Inst Nat Sci, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ, Grad Inst Nat Prod, Pingtung 907, Taiwan

[5] Natl Pingtung Univ Sci & Technol, Dept Forest Resources Management & Technol, Pingtung, Taiwan

来源：

PLANTA MEDICA | 2007年 / 73卷 / 06期

关键词：

D O I：

10.1055/s-2007-967195

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new epoxyfuranoid lignans, 4a,5a-epoxybeilschmin A (1), 4a,5a-epoxybeitschmin B (2), and beilschmin D (3), together with nine known compounds have been isolated from the leaves of Beilschmiedia tsangii. The structures of these new compounds were determined through spectral analyses. Among the isolates, beilschmin A (4) and beilschmin B (5) exhibited potent antitubercular activities (MICs = 2.5 and 7.5 mu g/mL, respectively) against Mycobacteriurn tuberculosis 90- 221387 in vitro.

引用

页码：567 / 571

页数：5

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