New cytotoxic tetrahydrofuran- and dihydrofuran-type lignans from the stem of Beilschmiedia tsangii

被引：55

作者：

Chen, JJ ^{[1
]}

Chou, ET

Duh, CY

Yang, SZ

Chen, IS

机构：

[1] Tajen Univ, Grad Inst Pharmaceut Technol, Pingtung 907, Taiwan

[2] Natl Sun Yat Sen Univ, Inst Marine Resources, Kaohsiung 80424, Taiwan

[3] Natl Pingtung Univ Sci & Technol, Dept Forest Resource Management & Technol, Pingtung, Taiwan

[4] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan

来源：

PLANTA MEDICA | 2006年 / 72卷 / 04期

关键词：

Beilschmiedia tsangii; Lauraceae; tetrahydrofuran-type lignans; beilschmin A; beilschmin B; dihydrofuran-type lignan; bedschmin C; -1-phenylbutyl benzoates; tsangin A; tsangin B; cytotoxicity;

D O I：

10.1055/s-2005-916220

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new compounds including two tetrahydrofuran-type lignans, beilschmin A and beilschmin B, a dihydrofuran-type lignan, bedschmin C, and two I-phenylbutyl benzoates, tsangin A and tsangin B, together with thirteen known compounds have been isolated from the stem of Beilschmiedia tsangii. The structures of these new compounds were determined through spectral analyses. Among the isolates, beilschmin A (1), beilschmin B (2), beilschmin C (3), tsangin A (4), tsangin B (5), 2,15,11-trinnethyl dodeca-2,6,1 0-triene (14), a-tocopherylqui none (17), and alpha-tocospiro B (18) were CYtOtOXiC (IC50 values < 4 mu g/mL) in P-388 and/or HT-29 cell lines in vitro.

引用

页码：351 / 357

页数：7

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