Requirement of intact sympathetic transmission for the ocular hypotensive effects of melatonin and 5-MCA-NAT

被引：17

作者：

Alarma-Estrany, Pilar ^{[1
]}

Crooke, Almudena ^{[1
]}

Peral, Assumpta ^{[2
]}

Pintor, Jesus ^{[1
]}

机构：

[1] Univ Complutense Madrid, Dept Bioquim, EU Opt, Madrid 28037, Spain

[2] Univ Complutense Madrid, Dept Opt, EU Opt Optometria & Vis 2, Madrid 28037, Spain

来源：

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2007年 / 137卷 / 1-2期

关键词：

5-MCA-NAT; glaucoma; intraocular pressure; melatonin; MT3 melatonin receptor;

D O I：

10.1016/j.autneu.2007.07.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Melatonin and its analogue, 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT), potently reduce intraocular pressure, and may be good candidates for the treatment of ocular hypertension and glaucoma. After chemical sympathectomy by reserpine or 6-hydroxydopamine, the hypotensive effects of melatonin and 5-MCA-NAT are severely inhibited. This indicates that the sympathetic nervous system is involved in the production and drainage of aqueous humour by the ciliary body and trabecular meshwork, and that it mediates the effects of melatonin and its analogue, 5-MCA-NAT. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：63 / 66

页数：4

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