Development and biological evaluation of potent and specific inhibitors of mitotic kinesin eg5

被引：152

作者：

Gartner, M

Sunder-Plassmann, N

Seiler, J

Utz, M

Vernos, I

Surrey, T

Giannis, A

机构：

[1] European Mol Biol Lab, Cell Biol & Biophys Programme, D-69117 Heidelberg, Germany

[2] Univ Leipzig, Inst Organ Chem, D-04103 Leipzig, Germany

来源：

CHEMBIOCHEM | 2005年 / 6卷 / 07期

关键词：

antitumor agents; inhibitors; monastrol; kinesin; structure-activity relationships;

D O I：

10.1002/cbic.200500005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Development and Biological Evaluation of Potent and Specific Inhibitors of Mitotic Kinesin Eg5

引用

页码：1173 / +

页数：6

共 27 条

[1]

SYNTHESIS OF CASEADINE METHYL ETHER [J].

CAVA, MP ;

LAKSHMIK.MV ;

MITCHELL, MJ .

JOURNAL OF ORGANIC CHEMISTRY, 1969, 34 (09) :2665-+

[2]

DeBonis S, 2004, MOL CANCER THER, V3, P1079

[3]

Microtubule polymerization dynamics [J].

Desai, A ;

Mitchison, TJ .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :83-117

[4]

LANTHANOIDS IN ORGANIC-SYNTHESIS .6. THE REDUCTION OF ALPHA-ENONES BY SODIUM-BOROHYDRIDE IN THE PRESENCE OF LANTHANOID CHLORIDES - SYNTHETIC AND MECHANISTIC ASPECTS [J].

GEMAL, AL ;

LUCHE, JL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (18) :5454-5459

[5]

Charge distribution from a simple molecular orbital type calculation and non-bonding interaction terms in the force field MAB [J].

Gerber, PR .

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 1998, 12 (01) :37-51

[6]

MAB, A GENERALLY APPLICABLE MOLECULAR-FORCE FIELD FOR STRUCTURE MODELING IN MEDICINAL CHEMISTRY [J].

GERBER, PR ;

MULLER, K .

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 1995, 9 (03) :251-268

[7]

Hadfield John A, 2003, Prog Cell Cycle Res, V5, P309

[8]

Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons [J].

Haque, SA ;

Hasaka, TP ;

Brooks, AD ;

Lobanov, PV ;

Baas, PW .

CELL MOTILITY AND THE CYTOSKELETON, 2004, 58 (01) :10-16

[9]

HR22C16: A potent small-molecule probe for the dynamics of cell division [J].

Hotha, S ;

Yarrow, JC ;

Yang, JG ;

Garrett, S ;

Renduchintala, KV ;

Mayer, TU ;

Kapoor, TM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (21) :2379-2382

[10]

Hotha S., 2003, ANGEW CHEM, V115, P2481

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