A whole genome association study in Finnish multiple sclerosis patients with 3669 markers

被引：13

作者：

Laaksonen, M

Jonasdottir, A

Fossdal, R

Ruutianen, J

Sawcer, S

Compston, A

Benediktsson, K

Thorlacius, T

Gulcher, J

Ilonen, J

机构：

[1] Univ Turku, Turku Immunol Ctr, FIN-20520 Turku, Finland

[2] Univ Turku, Dept Virol, FIN-20520 Turku, Finland

[3] Turku Univ Hosp, Dept Neurol, FIN-20520 Turku, Finland

[4] deCODE Genet, IS-101 Reykjavik, Iceland

[5] Masku Neurol Rehabil Ctr, Masku, Finland

[6] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 143卷 / 1-2期

关键词：

multiple sclerosis; association; DNA pooling; genomic screen; linkage disequilibrum; GAMES;

D O I：

10.1016/j.jneuroim.2003.08.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with complex genetic background. In the present study, based in the Finnish population, we typed a large number of microsatellite markers in separately pooled DNA samples from 195 MS patients and 205 controls. A total of 108 markers showed evidence of association. Five genomic regions containing two or more of these markers within a 1-Mb interval were identified, 1q43, 2p16, 4p15, 4q34 and 6p21 (the MHC region). Substantial overlap with previously published linkage genome screens is also seen. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：70 / 73

页数：4

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