In vivo three-dimensional optical coherence elastography

被引：144

作者：

Kennedy, Brendan F. ^{[1
]}

Liang, Xing ^{[2
,3
]}

Adie, Steven G. ^{[2
]}

Gerstmann, Derek K. ^{[4
,5
]}

Quirk, Bryden C. ^{[1
]}

Boppart, Stephen A. ^{[2
,3
,6
,7
]}

Sampson, David D. ^{[1
,4
]}

机构：

[1] Univ Western Australia, Sch Elect Elect & Comp Engn, Opt Biomed Engn Lab, Crawley, WA 6009, Australia

[2] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA

[3] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA

[4] Univ Western Australia, Ctr Microscopy Characterisat & Anal, Crawley, WA 6009, Australia

[5] Univ Western Australia, iVEC, Crawley, WA 6009, Australia

[6] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA

[7] Univ Illinois, Dept Med, Urbana, IL 61801 USA

来源：

OPTICS EXPRESS | 2011年 / 19卷 / 07期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

MAGNETIC-RESONANCE ELASTOGRAPHY; IMAGING ELASTIC PROPERTIES; TOMOGRAPHY; STRAIN; BREAST; DEFORMATION; DISEASE; TISSUES;

D O I：

10.1364/OE.19.006623

中图分类号：

O43 [光学];

学科分类号：

070207 [光学];

摘要：

We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum in the hydrated case. (C) 2011 Optical Society of America

引用

页码：6623 / 6634

页数：12

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