Audio frequency in vivo optical coherence elastography

被引：56

作者：

Adie, Steven G. ^{[1
]}

Kennedy, Brendan F. ^{[1
]}

Armstrong, Julian J. ^{[1
]}

Alexandrov, Sergey A. ^{[1
]}

Sampson, David D. ^{[1
]}

机构：

[1] Univ Western Australia, Sch Elect Engn & Comp Engn, OBEL, Nedlands, WA 6009, Australia

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2009年 / 54卷 / 10期

关键词：

IMAGING ELASTIC PROPERTIES; TISSUE; DEFORMATION; STRAIN;

D O I：

10.1088/0031-9155/54/10/011

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.

引用

页码：3129 / 3139

页数：11

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