Platform for enhanced detection efficiency in luminescence-based sensors

被引:19
作者
Blue, R [1 ]
Kent, N
Polerecky, L
McEvoy, H
Gray, D
MacCraith, BD
机构
[1] Dublin City Univ, Natl Ctr Sensor Res, Dublin 9, Ireland
[2] Max Planck Inst Marine Microbiol, Microsensors Grp, D-28359 Bremen, Germany
[3] Inst Elect Struct & Laser, GR-71110 Iraklion, Greece
关键词
D O I
10.1049/el:20050744
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 [电气工程]; 0809 [电子科学与技术];
摘要
Luminescence-based biochip measurement platforms are employed in a wide range of biological applications, such as biomedical diagnostics. Based on an understanding of the anisotropic emission properties of luminescence emitters close to a dielectric interface, a simple strategy for producing a better than 25-fold enhancement of the detected luminescence is presented. This strategy is demonstrated for low cost polymer platforms compatible with mass-production.
引用
收藏
页码:682 / 684
页数:3
相关论文
共 8 条
[1]
EGGINS BR, 1998, BIOSENSORS INTRO
[2]
Highly efficient optical detection of surface-generated fluorescence [J].
Enderlein, J ;
Ruckstuhl, T ;
Seeger, S .
APPLIED OPTICS, 1999, 38 (04) :724-732
[3]
ANGULAR-DISTRIBUTION OF FLUORESCENCE FROM LIQUIDS AND MONODISPERSED SPHERES BY EVANESCENT WAVE EXCITATION [J].
LEE, EH ;
BENNER, RE ;
FENN, JB ;
CHANG, RK .
APPLIED OPTICS, 1979, 18 (06) :862-868
[4]
Theory of the radiation of dipoles placed within a multilayer system [J].
Polerecki, L ;
Hamrle, J ;
MacCraith, BD .
APPLIED OPTICS, 2000, 39 (22) :3968-3977
[5]
POLERECKY L, 2002, Patent No. 05983
[6]
Array biosensor for simultaneous identification of bacterial, viral, and protein analytes [J].
Rowe, CA ;
Tender, LM ;
Feldstein, MJ ;
Golden, JP ;
Scruggs, SB ;
MacCraith, BD ;
Cras, JJ ;
Ligler, FS .
ANALYTICAL CHEMISTRY, 1999, 71 (17) :3846-3852
[7]
Supercritical angle fluorescence (SAF) microscopy [J].
Ruckstuhl, T ;
Verdes, D .
OPTICS EXPRESS, 2004, 12 (18) :4246-4254
[8]
Enhanced dipole-dipole interaction between elementary radiators near a surface [J].
Stuart, HR ;
Hall, DG .
PHYSICAL REVIEW LETTERS, 1998, 80 (25) :5663-5666