Lymphatic filariasis: parallels between the immunology of infection in humans and mice

被引：36

作者：

Lawrence, RA

Devaney, E

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

[2] Univ Glasgow, Dept Vet Parasitol, Glasgow G61 1QH, Lanark, Scotland

来源：

PARASITE IMMUNOLOGY | 2001年 / 23卷 / 07期

关键词：

antibodies; Brugia; filariasis; granulocytes; IFN-gamma; IL-4; IL-5; IL-10; protective immunity; T regulatory cells; neutrophils;

D O I：

10.1046/j.1365-3024.2001.00396.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mouse models of Brugia infection have provided much useful quantitative and qualitative information on the immune response elicited by different life cycle stages of filarial worms. Many parallels exist between the immune response in the mouse and the infected human and in this review we highlight areas of topical interest, including the induction of specific cytokine resposes and their role in immunomodulation and protective immunity. These studies have reinforced the concept that different life cycle stages of filarial parasites each have their own mechanism of modulating responses so that potentially inflammatory IFN-gamma responses are downregulated. While the precise mechanisms of protective immunity remain to be defined, studies in the mouse have suggested novel pathways, including a possible role for granulocytes.

引用

页码：353 / 361

页数：9

共 77 条

[11] Production of both IFN-gamma and IL-5 by Onchocerca volvulus S1 antigen-specific CD4(+) T cells from putatively immune individuals [J].