Fast preparation of a highly efficient organic monolith via photo-initiated thiol-ene click polymerization for capillary liquid chromatography

被引：48

作者：

Chen, Lianfang ^{[1
,2
]}

Ou, Junjie ^{[1
]}

Liu, Zhongshan ^{[1
,2
]}

Lin, Hui ^{[1
,2
]}

Wang, Hongwei ^{[1
]}

Dong, Jing ^{[1
]}

Zou, Hanfa ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY A | 2015年 / 1394卷

关键词：

Organic monolith; Thiol-ene click reaction; Capillary liquid chromatography; Photo-initiated polymerization; 1,2,4-Trivinylcyclohexane; POLYHEDRAL OLIGOMERIC SILSESQUIOXANES; LARGE SURFACE-AREA; STATIONARY PHASES; REVERSED-PHASE; MACROPOROUS POLYMERS; POROUS MATERIALS; SEPARATION; COLUMNS; PERFORMANCE; PROTEIN;

D O I：

10.1016/j.chroma.2015.03.054

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

A novel organic monolith was firstly prepared in a UV-transparent fused-silica capillary by a single-step approach via photo-initiated thiol-ene click polymerization reaction of 1,2,4-trivinylcyclohexane (TVCH) and pentaerythriol tetra(3-mercaptopropionate) (4SH) within 10 min. The effects of both composition of prepolymerization solution and polymerization time on the morphology and permeability of monolithic column were investigated in detail. Then, the optimal condition was acquired to fabricate a homogeneous and permeable organic monolith. The chemical groups of the monolithic column were confirmed by Fourier transform infrared spectroscopy (FT-IR). The SEM graphs showed the organic monolith possessed a uniform porous structure, which promotes the highest column efficiency of 133,000 plates per meter for alkylbenzenes at the linear velocity of 0.65 mm/s in reversed-phase liquid chromatography. Finally, the organic monolithic column was further applied for separation of basic compounds, pesticides and EPA610, indicating satisfactory separation ability. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：103 / 110

页数：8

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