Acid-labile core cross-linked micelles for pH-triggered release of antitumor drugs
被引:170
作者:
Chan, Yannie
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, CAMD, Sydney, NSW 2052, Australia
Chan, Yannie
[1
]
Wong, To
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, CAMD, Sydney, NSW 2052, Australia
Wong, To
[1
]
Byrne, Frances
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Canc Inst Australia Med Res, Sydney, NSW 2031, AustraliaUniv New S Wales, CAMD, Sydney, NSW 2052, Australia
Byrne, Frances
[2
]
Kavallaris, Maria
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Canc Inst Australia Med Res, Sydney, NSW 2031, AustraliaUniv New S Wales, CAMD, Sydney, NSW 2052, Australia
Kavallaris, Maria
[2
]
Bulmus, Volga
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, CAMD, Sydney, NSW 2052, Australia
Univ New S Wales, Sch Biotechnol & Biomol Sci BABS, Sydney, NSW 2052, AustraliaUniv New S Wales, CAMD, Sydney, NSW 2052, Australia
Bulmus, Volga
[1
,3
]
机构:
[1] Univ New S Wales, CAMD, Sydney, NSW 2052, Australia
[2] Childrens Canc Inst Australia Med Res, Sydney, NSW 2031, Australia
[3] Univ New S Wales, Sch Biotechnol & Biomol Sci BABS, Sydney, NSW 2052, Australia
Micelles of a model amphiphilic block copolymer, poly(hydroxyethyl acrylate)-block-poly(n-butyl acrylate) (PHEA-b-PBA), synthesized via the RAFT polymerization were cross-linked by copolymerization of a degradable crosslinker from the living RAFT-end groups of PBA chains, yielding a cross-linked core without affecting significantly the original micelle size. The cross-linker incorporation into the micelles was, evidenced via physicochemical analysis of the copolymer unimers formed upon acidic cleavage of the cross-linked micelles. High doxorubicin loading capacities (60 wt %) were obtained. Hydrolysis of less than half of the cross-links in the core was found to be sufficient to release doxorubicin faster at acidic pH compared to neutral pH. The system represents the first example of core-cross-linked micelles that can be destabilized (potentially both above and below CMC) by the pH-dependent cleavage of the cross-links and the subsequent polarity change in the core to enable the release of hydrophobic drugs entrapped inside the micelle.
机构:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, JapanUniv Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan
Bae, Y
;
Fukushima, S
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, JapanUniv Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan
Fukushima, S
;
Harada, A
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, JapanUniv Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan
Harada, A
;
Kataoka, K
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, JapanUniv Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan
机构:
UNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCEUNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCE
FIALLO, M
;
LAIGLE, A
论文数: 0引用数: 0
h-index: 0
机构:
UNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCEUNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCE
LAIGLE, A
;
BORREL, MN
论文数: 0引用数: 0
h-index: 0
机构:
UNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCEUNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCE
BORREL, MN
;
GARNIERSUILLEROT, A
论文数: 0引用数: 0
h-index: 0
机构:
UNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCEUNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCE
机构:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, JapanUniv Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan
Bae, Y
;
Fukushima, S
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, JapanUniv Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan
Fukushima, S
;
Harada, A
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, JapanUniv Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan
Harada, A
;
Kataoka, K
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, JapanUniv Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan
机构:
UNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCEUNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCE
FIALLO, M
;
LAIGLE, A
论文数: 0引用数: 0
h-index: 0
机构:
UNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCEUNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCE
LAIGLE, A
;
BORREL, MN
论文数: 0引用数: 0
h-index: 0
机构:
UNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCEUNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCE
BORREL, MN
;
GARNIERSUILLEROT, A
论文数: 0引用数: 0
h-index: 0
机构:
UNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCEUNIV PARIS 06,PHYS & CHIM BIOMOLEC LAB,CNRS,URA 198,F-75231 PARIS 05,FRANCE