Symmetric synaptic patterns between starburst amacrine cells and direction selective ganglion cells in the rabbit retina

被引:15
作者
Chen, Yung-Cheng [1 ]
Chiao, Chuan-Chin [2 ]
机构
[1] Natl Tsing Hua Univ, Inst Mol Med, Hsinchu 30013, Taiwan
[2] Natl Tsing Hua Univ, Dept Life Sci, Hsinchu 30013, Taiwan
关键词
cofasciculation; dendritic contacts; inhibitory synapses; GABA receptors;
D O I
10.1002/cne.21677
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Inputs from starburst amacrine cells (SACs) to ON-OFF direction selective ganglion cells (DSGCs) in the rabbit retina are themselves directional. However, the synaptic asymmetry between SACs and DSGCs required for generating direction selectivity has been controversial. We investigated dendritic contacts and distribution of inhibitory synapses between SACs and their overlapped DSGCs. Double injection of SAC/DSGC pairs and quantitative analysis revealed no obvious asymmetry of dendritic contacts between SACs and DSGCs. Furthermore, examination of the inhibitory input pattern on the dendrites of DSGCs using antibodies against GABA, receptors also suggested an isotropic arrangement with the overlapping SACs in both the preferred and the null directions. Therefore, the presynaptic mechanism of direction selectivity upon DSGCs may not result from a simple asymmetric arrangement with overlapping SACs. Multiple layer interactions and sophisticated synaptic connections between SACs and DSGCs are necessary.
引用
收藏
页码:175 / 183
页数:9
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