Structure-based and combinatorial search for new RNA-binding drugs

被引：52

作者：

Afshar, M

Prescott, CD

Varani, G

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[2] Ribotargets Ltd, Cambridge CB2 2JX, England

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0958-1669(99)80011-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery by structure-based and combinatorial methods of new RNA-binding drugs presents great opportunities for pharmacological development against drug-resistant bacterial and viral pathogens. A handful of recent RNA structures and more numerous studies of the interaction of combinatorial libraries and oligomeric RNA-binding compounds are providing the foundation for effective RNA-targeted drug discovery programs.

引用

页码：59 / 63

页数：5

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