Linking class-switch recombination with somatic hypermutation

被引：106

作者：

Kinoshita, K ^{[1
]}

Honjo, T ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Med Chem & Mol Biol, Sakyo Ku, Kyoto 6068501, Japan

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 07期

关键词：

D O I：

10.1038/35080033

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The recent discovery of a molecular link between two apparently different genetic alteration events - class-switch recombination and somatic hypermutation - has led to the idea that the recognition and cleavage of target DNA in these two events might be mediated by similar or identical molecules to those involved in RNA editing. This could mean that the complexity of mammalian genetic information may be enriched by an interplay between RNA editing and DNA modification.

引用

页码：493 / 503

页数：11

共 108 条

[31] INDEPENDENT CONTROL OF IMMUNOGLOBULIN SWITCH RECOMBINATION AT INDIVIDUAL SWITCH REGIONS EVIDENCED THROUGH CRE-IOXP-MEDIATED GENE TARGETING [J].

GU, H ;

ZOU, YR ;

RAJEWSKY, K .

CELL, 1993, 73 (06) :1155-1164

[32] ORGANIZATION OF IMMUNOGLOBULIN HEAVY-CHAIN GENES AND ALLELIC DELETION MODEL [J].

HONJO, T ;

KATAOKA, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (05) :2140-2144

[33] CIRCULAR DNA IS EXCISED BY IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION [J].

IWASATO, T ;

SHIMIZU, A ;

HONJO, T ;

YAMAGISHI, H .

CELL, 1990, 62 (01) :143-149

[34] Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice [J].

Jacobs, H ;

Fukita, Y ;

van der Horst, TJ ;

de Boer, J ;

Weeda, G ;

Essers, J ;

de Wind, N ;

Engelward, BP ;

Samson, L ;

Verbeek, S ;

de Murcia, JM ;

de Murcia, G ;

te Riele, H ;

Rajewsky, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (11) :1735-1743

[35] Towards an understanding of somatic hypermutation [J].

Jacobs, H ;

Bross, L .

CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (02) :208-218

[36] SHUTDOWN OF CLASS SWITCH RECOMBINATION BY DELETION OF A SWITCH REGION CONTROL ELEMENT [J].

JUNG, S ;

RAJEWSKY, K ;

RADBRUCH, A .

SCIENCE, 1993, 259 (5097) :984-987

[37] REARRANGEMENT OF IMMUNOGLOBULIN GAMMA-1-CHAIN GENE AND MECHANISM FOR HEAVY-CHAIN CLASS SWITCH [J].

KATAOKA, T ;

KAWAKAMI, T ;

TAKAHASHI, N ;

HONJO, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (02) :919-923

[38] Different mismatch repair deficiencies all have the same effects on somatic hypermutation: Intact primary mechanism accompanied by secondary modifications [J].

Kim, N ;

Bozek, G ;

Lo, JC ;

Storb, U .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (01) :21-30

[39] B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes [J].

Kim, N ;

Kage, K ;

Matsuda, F ;

Lefranc, MP ;

Storb, U .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (03) :413-419

[40] Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions [J].

Kinoshita, K ;

Tashiro, J ;

Tomita, S ;

Lee, CG ;

Honjo, T .

IMMUNITY, 1998, 9 (06) :849-858

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