Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats

被引：46

作者：

Dong, Deshi ^{[1
,2
]}

Yin, Lianhong ^{[1
]}

Qi, Yan ^{[1
]}

Xu, Lina ^{[1
]}

Peng, Jinyong ^{[1
]}

机构：

[1] Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China

[2] Dalian Med Univ, Affiliated Hosp 1, Dalian 116011, Peoples R China

来源：

NUTRIENTS | 2015年 / 7卷 / 06期

关键词：

protective effect; Rosa laevigata Michx; total saponins; liver fibrosis; HIGH-FAT DIET; HEPATIC-FIBROSIS; INJURY; INFLAMMATION; KINASE; ANTIOXIDANT; MECHANISMS; EXPRESSION; FLAVONOIDS; CYTOKINES;

D O I：

10.3390/nu7064829

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

In this study, the protective effect of the total saponins from Rosa laevigata Michx (RLTS) against liver fibrosis induced by carbon tetrachloride (CCl4) in rats was evaluated. The results showed that RLTS significantly rehabilitated the levels of alanine aminotransferase, aspartate aminotransferase, malondialdehyde, glutathione, glutathione peroxidase, catalase, superoxide dismutase, hydroxyproline, -smooth muscle actin, collagen I, collagen III and fibronectin, which were confirmed using H&E, Sirius Red and Masson histopathological assays. Further research indicated that RLTS markedly reduced cytochrome P450 2E1 activity, attenuated oxidative stress, and suppressed inflammation. In addition, RLTS facilitated matrix degradation through down-regulation of matrix metalloproteinase2, matrix metalloproteinase 9 and metalloproteinases1, and exerted the anti-fibrotic effects through affecting transforming growth factor /Smad, focal adhesion kinase/phosphatidylinositol-3-kinase/amino kinase terminal/70-kDa ribosomal S6 Kinase (FAK-PI3K-Akt-p70(S6K)) and mitogen-activated protein kinase (MAPK) signaling pathways. Taken together, our data indicate that RLTS can be applied as one effective candidate for the treatment of liver fibrosis in the future.

引用

页码：4829 / 4850

页数：22

共 49 条

[1]

[Anonymous], J BIOL

[2]

[Anonymous], 1955, PHARM ZENTRALHALLE D

[3]

Liver fibrosis [J].