Sequential Ugi/Heck cyclization strategies for the facile construction of highly functionalized N-heterocyclic scaffolds

被引：81

作者：

Gracias, V ^{[1
]}

Moore, JD ^{[1
]}

Djuric, SW ^{[1
]}

机构：

[1] Abbott Labs, Abbott Pk, IL 60064 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 02期

关键词：

Ugi; Heck; multi-component reaction; solid-phase; scaffold;

D O I：

10.1016/j.tetlet.2003.10.147

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy employing an Ugi four-component reaction and a microwave-assisted intramolecular Heck cyclization in a sequential fashion to access an array of N-containing heterocycles is reported. The two-step sequence generated compounds of significant molecular complexity from trivial starting materials in an expedient fashion with excellent yields. The route was also amenable to solid-phase chemistry demonstrating potential for library generation. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：417 / 420

页数：4

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