Solid phase synthesis of fused bicyclic amino acid derivatives via intramolecular Pauson-Khand cyclization: Versatile scaffolds for combinatorial chemistry.

被引：68

作者：

Bolton, GL

Hodges, JC

Rubin, JR

机构：

来源：

TETRAHEDRON | 1997年 / 53卷 / 19期

关键词：

D O I：

10.1016/S0040-4020(97)00220-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solution and solid phase synthetic methods leading to the rapid, stereocontrolled construction of highly functionalized fused bicyclic amino acid derivatives have been developed. The key step involves a unique application of the intramolecular Pauson-Khand cyclization for the construction of hexahydro-1H-[2]pyrindinone ring systems. Further modifications which demonstrate the potential for combinatorial library generation are also disclosed. (C) 1997 Published by Elsevier Science Ltd.

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页码：6611 / 6634

页数：24

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