Secondary inhibition of 2-ketoglutarate dehydrogenase complex by MPTP

被引：13

作者：

Joffe, GT

Parks, JK

Parker, WD ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Dept Neurol, Charlottesville, VA 22901 USA

[2] Univ Virginia, Sch Med, Dept Pediat, Charlottesville, VA 22901 USA

[3] Univ Virginia, Sch Med, Dept Neurosci, Charlottesville, VA 22901 USA

[4] Univ Virginia, Sch Med, Ctr Study Neurodegenerat Dis, Charlottesville, VA 22901 USA

来源：

NEUROREPORT | 1998年 / 9卷 / 12期

关键词：

2-ketoglutarate dehydrogenase complex; MPP+; MPTP;

D O I：

10.1097/00001756-199808240-00018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridine (MPP+) acts through inhibition of complex I of the electron transport chain. Recent evidence suggests that it may also act through inhibition of 2-ketoglutarate dehydrogenase complex (KDHC). We confirmed this observation in isolated rat liver mitochondria but found that this inhibition is prevented by preincubation with the radical quencher, cysteine (Cys). KDHC is also inhibited by the NO generator S-nitroso-N-acetyl-penicillamine (SNAP) and this inhibition is similarly blocked by cysteine. MPP+ may inhibit KDHC secondary through a radical-mediated event rather than through direct interaction with KDHC. (C) 1998 Lippincott Williams & Wilkins.

引用

页码：2781 / 2783

页数：3

共 19 条

[1] PERMANENT HUMAN PARKINSONISM DUE TO 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) - 7 CASES [J].