INHIBITION OF MITOCHONDRIAL ALPHA-KETOGLUTARATE DEHYDROGENASE BY 1-METHYL-4-PHENYLPYRIDINIUM ION

被引：79

作者：

MIZUNO, Y ^{[1
]}

SAITOH, T ^{[1
]}

SONE, N ^{[1
]}

机构：

[1] JICHI MED SCH,DEPT BIOCHEM,MINAMIKAWACHI,TOCHIGI 32904,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1987年 / 143卷 / 03期

关键词：

D O I：

10.1016/0006-291X(87)90346-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：971 / 976

页数：6

共 22 条

[1] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].

CHIBA, K ;

TREVOR, A ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578

[2] 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) AND 1-METHYL-4-PHENYLPYRIDINE (MPP+) CAUSE RAPID ATP DEPLETION IN ISOLATED HEPATOCYTES [J].

DIMONTE, D ;

JEWELL, SA ;

EKSTROM, G ;

SANDY, MS ;

SMITH, MT .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 137 (01) :310-315

[3]

ENGLARD S, 1969, METHOD ENZYMOL, V13, P99

[4] LOCUS-CERULEUS LESIONS AND EOSINOPHILIC INCLUSIONS IN MPTP-TREATED MONKEYS [J].

FORNO, LS ;

LANGSTON, JW ;

DELANNEY, LE ;

IRWIN, I ;

RICAURTE, GA .

ANNALS OF NEUROLOGY, 1986, 20 (04) :449-455

[5] DOPAMINERGIC TOXICITY OF ROTENONE AND THE 1-METHYL-4-PHENYLPYRIDINIUM ION AFTER THEIR STEREOTAXIC ADMINISTRATION TO RATS - IMPLICATION FOR THE MECHANISM OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE TOXICITY [J].

HEIKKILA, RE ;

NICKLAS, WJ ;

VYAS, I ;

DUVOISIN, RC .

NEUROSCIENCE LETTERS, 1985, 62 (03) :389-394

[6] SELECTIVE ACCUMULATION OF MPP+ IN THE SUBSTANTIA NIGRA - A KEY TO NEUROTOXICITY [J].

IRWIN, I ;

LANGSTON, JW .

LIFE SCIENCES, 1985, 36 (03) :207-212

[7] 1-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) - IDENTIFICATION OF A METABOLITE OF MPTP, A TOXIN SELECTIVE TO THE SUBSTANTIA NIGRA [J].

LANGSTON, JW ;

IRWIN, I ;

LANGSTON, EB ;

FORNO, LS .

NEUROSCIENCE LETTERS, 1984, 48 (01) :87-92

[8]

LOWRY OH, 1951, J BIOL CHEM, V258, P2285

[9] DOPAMINERGIC NEUROTOXINS, MPTP AND MPP+, INHIBIT ACTIVITY OF MITOCHONDRIAL NADH-UBIQUINONE OXIDOREDUCTASE [J].

MIZUNO, Y ;

SONE, N ;

SAITOH, T .

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1986, 62 (07) :261-263

[10]

MIZUNO Y, 1987, IN PRESS J NEUROCHEM

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