SELECTIVE ACCUMULATION OF MPP+ IN THE SUBSTANTIA NIGRA - A KEY TO NEUROTOXICITY

被引:159
作者
IRWIN, I [1 ]
LANGSTON, JW [1 ]
机构
[1] SANTA CLARA VALLEY MED CTR,SAN JOSE,CA 95128
关键词
D O I
10.1016/0024-3205(85)90060-8
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:207 / 212
页数:6
相关论文
共 13 条
  • [1] BALLARD PA, NEUROLOGY NY
  • [2] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
    BURNS, RS
    CHIUEH, CC
    MARKEY, SP
    EBERT, MH
    JACOBOWITZ, DM
    KOPIN, IJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14): : 4546 - 4550
  • [3] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE
    CHIBA, K
    TREVOR, A
    CASTAGNOLI, N
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) : 574 - 578
  • [4] CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS
    DAVIS, GC
    WILLIAMS, AC
    MARKEY, SP
    EBERT, MH
    CAINE, ED
    REICHERT, CM
    KOPIN, IJ
    [J]. PSYCHIATRY RESEARCH, 1979, 1 (03) : 249 - 254
  • [5] CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS
    LANGSTON, JW
    BALLARD, P
    TETRUD, JW
    IRWIN, I
    [J]. SCIENCE, 1983, 219 (4587) : 979 - 980
  • [6] PARGYLINE PREVENTS MPTP-INDUCED PARKINSONISM IN PRIMATES
    LANGSTON, JW
    IRWIN, I
    LANGSTON, EB
    FORNO, LS
    [J]. SCIENCE, 1984, 225 (4669) : 1480 - 1482
  • [7] 1-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) - IDENTIFICATION OF A METABOLITE OF MPTP, A TOXIN SELECTIVE TO THE SUBSTANTIA NIGRA
    LANGSTON, JW
    IRWIN, I
    LANGSTON, EB
    FORNO, LS
    [J]. NEUROSCIENCE LETTERS, 1984, 48 (01) : 87 - 92
  • [8] LANGSTON JW, 1984, BR RES, V292, P391
  • [9] LYDEN A, 1983, ACTA PHARMACOL TOX, V53, P429
  • [10] LYLE RE, 1962, TETRAHEDRON LETT, V13, P553