The novel cyclopropapyrroloindole(CPI) bisalkylators bearing methoxycarbonyl and trifluoromethyl groups

被引：10

作者：

Fukuda, Y ^{[1
]}

Furuta, H

Kusama, Y

Ebisu, H

Oomori, Y

Terashima, S

机构：

[1] Kyorin Pharmaceut Co Ltd, Cent Res Labs, Nogi, Tochigi 3290114, Japan

[2] Sagami Chem Res Ctr, Sagamihara, Kanagawa 2290012, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(98)00235-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The novel 3-methoxycarbonyl-2-trifluoromethylcyclopropapyrroloindole (MCTFCPI) bisalkylators were synthesized and their antitumor activity was evaluated. Among these derivatives, 7f in which two MCTFCPI moieties are connected with a 5,5'-bis(2-carbonyl-1 H-indole) group, was found to exhibit more prominent cytotoxicity and antitumor activity than U-77,779 (bizelesin) (2). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1387 / 1390

页数：4

共 15 条

[1] SYNTHESIS OF 3-ARYLPYRROLES AND 3-PYRROLYLACETYLENES BY PALLADIUM-CATALYZED COUPLING REACTIONS [J].

ALVAREZ, A ;

GUZMAN, A ;

RUIZ, A ;

VELARDE, E ;

MUCHOWSKI, JM .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (06) :1653-1656

[2] A NOVEL PROPERTY OF DUOCARMYCIN AND ITS ANALOGS FOR COVALENT REACTION WITH DNA [J].

ASAI, A ;

NAGAMURA, S ;

SAITO, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (10) :4171-4177

[3]

CHESHMARITASHVILI MG, 1984, KHIM GETEROTSIKL+, P73

[4] Synthesis and antitumor activity of novel cyclopropapyrroloindole (CPI) derivatives bearing methoxycarbonyl and trifluoromethyl groups [J].

Fukuda, Y ;

Furuta, H ;

Shiga, F ;

Oomori, Y ;

Kusama, Y ;

Ebisu, H ;

Terashima, S .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (13) :1683-1688

[5] Novel syntheses of optically active CC-1065, U-73,975 (adozelesin), U-80,244 (carzelesin), U-77,779 (bizelesin), KW-2189, and DU-86 [J].

Fukuda, Y ;

Furuta, H ;

Shiga, F ;

Asahina, Y ;

Terashima, S .

HETEROCYCLES, 1997, 45 (12) :2303-2308

[6]

FUKUDA Y, UNPUB

[7]

LI LH, 1992, CANCER RES, V52, P4904

[8] INTERSTRAND DNA CROSS-LINKING WITH DIMERS OF THE SPIROCYCLOPROPYL ALKYLATING MOIETY OF CC-1065 [J].

MITCHELL, MA ;

JOHNSON, PD ;

WILLIAMS, MG ;

ARISTOFF, PA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (16) :6428-6429

[9] SYNTHESIS AND DNA CROSS-LINKING BY A RIGID CPI DIMER [J].

MITCHELL, MA ;

KELLY, RC ;

WICNIENSKI, NA ;

HATZENBUHLER, NT ;

WILLIAMS, MG ;

PETZOLD, GL ;

SLIGHTOM, JL ;

SIEMIENIAK, DR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (23) :8994-8995

[10]

SAMSONIYA SA, 1981, KHIM GETEROTSIKL+, P57

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