Using STN DBS and medication reduction as a strategy to treat pathological gambling in Parkinson's disease

被引：93

作者：

Bandini, Fabio ^{[1
]}

Primavera, Alberto ^{[1
]}

Pizzorno, Matteo ^{[1
]}

Cocito, Leonardo ^{[1
]}

机构：

[1] Univ Genoa, Dept Neurosci Ophthalmol & Genet, I-16132 Genoa, Italy

来源：

PARKINSONISM & RELATED DISORDERS | 2007年 / 13卷 / 06期

关键词：

Parkinson's disease; pathological gambling; dopaminergic therapy; subthalamic nucleus deep brain stimulation;

D O I：

10.1016/j.parkreldis.2006.07.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe two patients with Parkinson's disease (PD) who developed clinical criteria of pathological gambling addiction in the setting of increased dopamine replacement therapy (levodopa and dopamine agonist medications). The second patient showed also signs of dopamine dysregulation syndrome, with an addiction to dopaminergic medication. Neither patients responded to the standard therapy for gambling behavior, but dramatically improved after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) and early postoperative withdrawal of dopaminergic therapy. The possible therapeutic role of subthalamic nucleus deep brain Stimulation (STN-DBS) on such a disabling behavior needs to be investigated prospectively. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：369 / 371

页数：3

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