Increased serum S100B protein in schizophrenia: a study in medication-free patients

被引：121

作者：

Lara, DR

Gama, CS

Belmonte-de-Abreu, P

Portela, LVC

Goncalves, CA

Fonseca, M

Hauck, S

Souza, DO

机构：

[1] Univ Fed Rio Grande do Sul, Dept Biochem, Inst Ciencias Basicas Saude, BR-90035003 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Dept Psychiat, Hosp Clin Porto Alegre, BR-90035003 Porto Alegre, RS, Brazil

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2001年 / 35卷 / 01期

关键词：

schizophrenia S100B protein; neurodegeneration; glia; astrocytes;

D O I：

10.1016/S0022-3956(01)00003-6

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

S100B protein, a calcium binding protein produced and released by glial cells, has been used as a sensitive marker of brain damage. Previous studies have found alterations in peripheral S100B levels in schizophrenic patients on medication. We compared serum S100B levels of 20 medication-free DSM-IV schizophrenic patients and 20 age-gender matched healthy controls. Schizophrenic patients presented higher serum S100B levels (mean 0.120 ng/ml +/-S.D. 0.140) compared to controls (mean 0.066 ng/ml +/-S.D. 0.067; P = 0.014) and there was a negative correlation with illness duration (r = -0.496. P = 0.031). The results of this study indicate that serum S100B levels may be a state marker of a limited neurodegenerative process. particularly in the early course of schizophrenia or, at least, in a subgroup of schizophrenic patients. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：11 / 14

页数：4

共 20 条

[11]

Hu JR, 1997, J NEUROCHEM, V69, P2294

[12] Traumatic brain damage in minor head injury: Relation of serum S-100 protein measurements to magnetic resonance imaging and neurobehavioral outcome [J].