Mechanism of vitamin D action and its regulation

被引：65

作者：

Dusso, AS ^{[1
]}

Brown, AJ ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Div Renal, St Louis, MO 63110 USA

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1998年 / 32卷 / 02期

关键词：

vitamin D receptor; 1,25(OH)(2)D-3 genomic actions; 1,25(OH)(2)D-3 transcriptional regulation; regulation of vitamin D action;

D O I：

10.1053/ajkd.1998.v32.pm9808140

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Most of the biological actions of 1,25(OH)(2)D-3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily. The VDR functions as a ligand-induced transcription factor regulating the rate of expression of genes involved not only in the control of calcium homeostasis and bone remodeling, but also in immunomodulation, the control of hormone secretion, inhibition of cell growth, and induction of cell differentiation. This section discusses the molecular mechanisms involved in the transcriptional control of gene expression by 1,25(OH)(2)D-3. (C) 1998 by the National Kidney Foundation, Inc.

引用

页码：S13 / S24

页数：12

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