Novel alkaloids of the aaptamine class from an Indonesian marine sponge of the genus Xestopongia

被引：75

作者：

Calcul, L

Longeon, A

Al Mourabit, A

Guyot, M

Bourguet-Kondracki, ML

机构：

[1] CNRS, Museum Natl Hist Nat, Chim Lab, F-75005 Paris, France

[2] CNRS, ICSN, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON | 2003年 / 59卷 / 34期

关键词：

Xestospongia sp; sponge metabolites; alkaloids; aaptamine; benzo[de] [1,6]naphthyridine; triaza-pyrene; triaza-cyclopenta[cd]-phenalene; antibiotic; cytotoxic activity;

D O I：

10.1016/S0040-4020(03)01069-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Four novel alkaloids of the aaptamine class have been isolated in addition to the known aaptamine, isoaaptamine, demethyl(oxy)aaptamine and its dimethylketal from an unidentified species of Indonesian marine sponge of the genus Xestospongia. Their structures were elucidated on the basis of detailed 1D and 2D NMR spectroscopic data. Their antimicrobial activity was tested towards Gram (+) (S. aureus), Gram (-) (E. coli, V. anguillarum) bacterial strains, a fungus (C tropicalis); their cytotoxic activity was evaluated against KB cells. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6539 / 6544

页数：6

共 20 条

[1]

CHEMISTRY OF SPONGES .14. AAPTAMINE, A TAXONOMIC MARKER FOR SPONGES OF THE ORDER HADROMERIDA [J].