L-(+)-swainsonine and other pyrrolidine inhibitors of naringinase: Through an enzymic looking glass from D-mannosidase to L-rhamnosidase?

被引：64

作者：

Davis, B

Bell, AA

Nash, RJ

Watson, AA

Griffiths, RC

Jones, MG

Smith, C

Fleet, GWJ

机构：

[1] UNIV OXFORD,OXFORD CTR MOL SCI,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[2] INST GRASSLAND & ENVIRONM RES,ABERYSTWYTH SY23 3EB,CARDIGANSHIRE,WALES

[3] UNIV WALES,INST BIOL SCI,ABERYSTWYTH SY23 3DD,CARDIGANSHIRE,WALES

[4] GLAXO WELLCOME RES & DEV LTD,MED RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 47期

关键词：

D O I：

10.1016/0040-4039(96)01957-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and inhibitory properties towards naringinase (L-rhamnosidase) of L-(+)-swainsonine and of a number of more analogues, and of some monocyclic equivalents, are reported. L-(+)-swainsonine and 1,4,6-trideoxy-1,4-imino-L-mannitol are powerful and specific inhibitors of naringinase. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8565 / 8568

页数：4

共 15 条

[1]

ASANO N, 1994, J MED CHEM, V37, P3706

[2] TETRAZOLES OF MANNO-PYRANOSES AND RHAMNO-PYRANOSES - INHIBITION OF GLYCOSIDASES BY TETRAZOLES AND OTHER MANNOSE MIMICS [J].