Simple Synthesis and Functionalization of Iron Nanoparticles for Magnetic Resonance Imaging

被引：137

作者：

Cheong, Soshan ^{[3
,4
]}

Ferguson, Peter ^{[5
]}

Feindel, Kirk W. ^{[1
,2
]}

Hermans, Ian F. ^{[5
]}

Callaghan, Paul T. ^{[1
,2
]}

Meyer, Claire ^{[6
,7
]}

Slocombe, Angela ^{[8
]}

Su, Chia-Hao ^{[9
]}

Cheng, Fong-Yu ^{[10
,11
]}

Yeh, Chen-Sheng ^{[10
,11
]}

Ingham, Bridget ^{[3
,4
]}

Toney, Michael F. ^{[12
]}

Tilley, Richard D. ^{[1
,2
]}

机构：

[1] Victoria Univ Wellington, Sch Chem & Phys Sci, Wellington 6012, New Zealand

[2] Victoria Univ Wellington, MacDiarmid Inst Adv Mat & Nanotechnol, Wellington 6012, New Zealand

[3] Ind Res Ltd, Lower Hutt 5040, New Zealand

[4] MacDiarmid Inst Adv Mat & Nanotechnol, Lower Hutt 5040, New Zealand

[5] Malaghan Inst Med Res, Wellington 6012, New Zealand

[6] CNRS, Inst Neel, Grenoble, France

[7] UJF, Grenoble, France

[8] Wellington Hosp, Dept Radiol, Wellington 6021, New Zealand

[9] Chang Gung Mem Hosp, Kaohsiung Med Ctr, Ctr Translat Res Biomed Sci, Kaohsiung 833, Taiwan

[10] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan

[11] Natl Cheng Kung Univ, Ctr Micronano Technol Res, Tainan 701, Taiwan

[12] Stanford Synchrotron Radiat Lightsource, SLAC Natl Accelerator Lab, Menlo Pk, CA 94025 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 18期

基金：

加拿大自然科学与工程研究理事会;

关键词：

imaging agents; iron oxide; magnetic resonance imaging; nanoparticles; OXIDE NANOPARTICLES; STABILIZATION; OXIDATION;

D O I：

10.1002/anie.201100562

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Visualizing small tumors: A novel, facile synthesis leads to the formation of strongly magnetic single-crystal core/shell iron/iron oxide nanoparticles without the use of highly toxic chemicals. The core/shell nanoparticles are highly effective MRI contrast agents and enable unambiguous detection of small tumors of 1-3 mm in vivo (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4206 / 4209

页数：4

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