Palladium-catalyzed oxidative cyclization of enynes with hydrogen peroxide as the oxidant

被引：114

作者：

Yin, Guoyin ^{[1
]}

Liu, Guosheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 29期

关键词：

cyclization; enynes; hydrogen peroxide; oxidation; palladium;

D O I：

10.1002/anie.200801438

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Gently does it: The Pd-catalyzed oxidative cyclization of enynes with hydrogen peroxide, a simple, inexpensive, and environmental benign oxidant, is proposed to proceed through a catalytic Pd II/PdIV cycle in which the key C-Cl bond-forming step is the formation of a PdIV intermediate (see scheme). This is followed by a direct reductive elimination to generate C-Cl bonds with retention of the configuration of the C(sp3) center. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5442 / 5445

页数：4