A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases

被引：38

作者：

Mazzucco, S

Matà, S

Vergelli, M

Fioresi, R

Nardi, E

Mazzanti, B

Chelli, M

Lolli, F

Ginanneschi, D

Pinto, F

Massacesi, L

Papini, AM

机构：

[1] Univ Florence, Dipartimento Chim Organ Ugo Schiff, I-50121 Florence, Italy

[2] Univ Florence, CNR, Ctr Studio Chim & Struttura Composti Eterociclici, I-50121 Florence, Italy

[3] Univ Florence, I-50121 Florence, Italy

[4] Univ Florence, Dipartartimento Sci Neurol & Psichiatr, Serv Neurofisiopatol, I-50134 Florence, Italy

[5] Univ Florence, Dipartiemento Sci Neurol & Psichiatr, I-50134 Florence, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 02期

关键词：

MOG; glycopeptides; multiple sclerosis; antibodies;

D O I：

10.1016/S0960-894X(98)00698-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Glycopeptides of hMOG(30-50) containing a glucosyl moiety on the side-chains of Asn, Ser or Hyp at position 31 were synthesised. Antibody titres to hMOG(30-50) and to its glucoderivatives were measured by ELISA in sera of patients affected by different neurological diseases. Anti-hMOG(30-50) antibodies were detected only using the glycopeptide [Asn(31)(N-Glc)]hMOG(30-50). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：167 / 172

页数：6

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