Polymer stability plays an important role in the positional regulation of FtsZ

被引：48

作者：

Levin, PA

Schwartz, RL

Grossman, AD

机构：

[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

JOURNAL OF BACTERIOLOGY | 2001年 / 183卷 / 18期

关键词：

D O I：

10.1128/JB.183.18.5449-5452.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We conducted a series of experiments examining the effect of polymer stability on FtsZ localization dynamics in Bacillus subtilis. A loss-of-function mutation in ezrA, a putative polymer-destabilizing factor, suppresses the defects in FtsZ polymer stability associated with minCD overexpression. In addition, a mutation that is predicted to stabilize the FtsZ polymer leads to the formation of polar FtsZ rings. These data support the hypothesis that carefully balanced polymer stability is important for the assembly and localization of FtsZ during the bacterial cell cycle.

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页码：5449 / 5452

页数：4

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