Expression of transforming growth factor-β1, 2, 3 isoforms and type I and II receptors in acute focal cerebral ischemia:: an immunohistochemical study in rat after transient and permanent occlusion of middle cerebral artery

被引:45
作者
Ata, KA [1 ]
Lennmyr, F
Funa, K
Olsson, Y
Terént, A
机构
[1] Univ Uppsala Hosp, Res Grp Neuropathol, Dept Genet & Pathol, S-75185 Uppsala, Sweden
[2] Univ Uppsala Hosp, Dept Med Sci, Uppsala, Sweden
[3] Univ Gothenburg, Inst Anat & Cell Biol, Gothenburg, Sweden
关键词
brain infarct; rat brain; transforming growth factor-beta; middle cerebral artery occlusion; receptor;
D O I
10.1007/s004010051013
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Transforming growth factor beta (TGF-beta) is involved in the modulation of cell growth, differentiation and repair following injury of various organs. Previous studies on human autopsy material have indicated that TGF-beta isoforms -beta 1, -beta 2 and -beta 3, and TGF-beta receptor type I are expressed in various cells of necrotizing brain lesions like infarction and abscess. The present immunohistochemical study was designed to investigate changes that may occur with regard to TGF-beta and its receptors type I and II in a rat model of focal brain ischemia induced by transient or permanent occlusion of the middle cerebral artery. Our findings indicate that at days 1 and 3 following such transient and permanent ischemia there is an up-regulation of TGF-beta isoforms -beta 1, -beta 2 and -beta 3, and TGF-beta receptor types I and II mainly in the perifocal neurons, reactive astroglial cells, endothelial cells and macrophages.
引用
收藏
页码:447 / 455
页数:9
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