The role of PFA-100® testing in the investigation and management of haemostatic defects in children and adults

被引:121
作者
Harrison, P [1 ]
机构
[1] Churchill Hosp, Oxford Haemphilia Ctr, Oxford OX3 7JL, England
[2] Churchill Hosp, Thrombosis Unit, Oxford OX3 7JL, England
关键词
PFA-100 (R); platelet function testing; aggregometry; bleeding time; high shear;
D O I
10.1111/j.1365-2141.2005.05511.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The PFA-100 (R) provides a simple global measure of high shear-dependent platelet function, and as such is not diagnostic or specific to any disorder. Prolonged closure times must be interpreted in conjunction with a full blood count, von Willebrand factor (VWF) screen and other platelet tests. The PFA-100((R)) may also give false negative results with relatively common platelet defects. If clinical suspicion is high, further detailed platelet function testing and VWF screening are required to exclude abnormal platelet function, even if the PFA-100((R)) is normal. In more recent studies the PFA-100((R)) has been used for preoperative identification and management of surgical patients with haemostatic defects and for assessing the clinical effectiveness of platelet transfusion therapy. This review highlights the up to date, evidence-based, advantages and disadvantages of the PFA-100((R)) test in the investigation and management of haemostatic disorders in both children and adults.
引用
收藏
页码:3 / 10
页数:8
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