Polyisoprenoids: Structure, biosynthesis and function

被引：175

作者：

Swiezewska, E

Danikiewicz, W

机构：

[1] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland

[2] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland

来源：

PROGRESS IN LIPID RESEARCH | 2005年 / 44卷 / 04期

关键词：

prenol; dolichol; polyisoprenoid; metabolism of isoprenoids;

D O I：

10.1016/j.plipres.2005.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The polyisoprenoid alcohols and their derivatives are highlighted here. These linear polymers of isoprenoid residues are widespread in nature from bacteria to human cells. This review presents their structures, distribution and biogenesis. Attention will be focused on the biosynthesis of polyisoprenoid alcohols in plants in the context of two coexisting isoprenoid pathways, mevalonate and the recently described methylerythritol phosphate pathway. Structural aspects including modeling of the polyisoprenoid conformation will be presented and finally the postulated biological role of polyisoprenoid alcohols will be discussed including polyisoprenylation of proteins. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：235 / 258

页数：24

共 189 条

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